Does magnesium protect against Parkinson’s disease?

Dietary intake of magnesium has been shown to improve many clinical conditions like cancer, depression, asthma, and neurodegenerative diseases. Several lines of research evidence show a possible therapeutic role of magnesium for Parkinson’s disease. There are studies showing that low level of magnesium in the brain increases the risk of developing Parkinson’s disease.

Magnesium – the most imperative mineral

Magnesium (Mg) is the most abundant element that is involved in a wide range of biochemical processes in the body including energy generation, DNA, RNA, and protein synthesis, and cell growth. It is essential for the proper functions of the brain, heart, and muscle. It is also crucial for your bone development.

Mg is abundant in plant and animal foods. It can be found in green leafy vegetables, nuts, whole grains, cereals, legumes, potatoes, rice, milk, fruits, chicken, beef, and salmon.

Magnesium and risk of Parkinson’s disease

Lately, there has been a growing interest in the protective role of Mg in Parkinson’s disease. While the specific role of Mg in the development of Parkinson’s disease has not been explored yet, a study conducted in Japan showed that low consumption of Mg increases the risk of Parkinson’s disease. In this study, 249 Parkinson’s patients and 368 controls without brain diseases were examined for their metal consumption. The study concluded that higher intake of Mg decreased the risk of developing Parkinson’s disease (1).

Earlier before this study, it was reported that Mg concentration in the brain of Parkinson’s patients decreases with progression of the disease. In this report, brains from 9 Parkinson’s disease patients and 12 control subjects were analyzed for different metals. Mg level was found substantially lower in Parkinson’s disease brains compared to control brains (2).  Similar kinds of results were also observed in other studies (3 4).

Overall, these studies suggest that Mg has the therapeutic potential to protect the brain from developing Parkinson’s disease.

But how does magnesium cause such a protective effect?

In Parkinson’s disease, the brain becomes unable to sufficiently produce the neurotransmitter dopamine, which is responsible for controlled movement. This is due to the death of certain cells called the dopaminergic neurons.

Researchers think that Mg might act to protect the death of these dopaminergic neurons in the brain. This neuroprotective effect is attributed to its ability to inhibit the generation of oxidative stress, a process that caused the loss of dopaminergic neurons in the brain.

In a study performed on rats, Mg was found protective against the oxidative stress-dependent loss of brain cells. In this study, when brain cells from 1-year old rats were exposed to a neurotoxin, called MPP+, that caused oxidative stress damage to the brain, a significant loss of dopaminergic neurons was observed. But when the same brain cells were treated with high concentration of Mg before exposing to MPP, the loss of dopaminergic neurons was rescued (5).

Can dietary magnesium control the symptoms of Parkinson’s disease?

While the dietary intake of Mg has been shown to reduce the risk of developing Parkinson’s disease, whether it relieves the symptoms of the disease is still uncertain. There are some anecdotal evidence suggests that high consumption of Mg could help with relieving some symptoms of the disease. For some people that have tried it are convinced that it works. They got improvement in their tremor and movement (6). On the contrary, there are people who reported that their symptoms become worse due to high intake of Mg. Therefore, one must be cautious and should take the advice of his doctor before using it.

Final Words

Dietary intake of Mg can be helpful and protective against Parkinson’s disease. There is some evidence that its consumption reduce the risk of Parkinson’s disease. But whether it can stop the disease progression is uncertain. Some people use Mg supplements to manage their symptoms. However, supplementation can badly affect the efficacy of certain medications. Therefore, if you wish to start taking Mg supplements, take the advice of your doctor first to see if it’s a good choice for you.

Disclaimer: The information shared here should not be taken as medical advice. The opinions presented here are not intended to treat any health conditions. For your specific medical problem, consult with your health care provider.

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